OUR recent PAPERS

Structural and functional conservation of non-lumenized lymphatic endothelial cells in the mammalian leptomeninges

Shannon Shibata-Germanos, James R. Goodman, Alan Grieg, Chintan A. Trivedi, Bridget C. Benson, Sandrine C. Foti, Ana Faro, Raphael F. P. Castellan, Rosa Maria Correra, Melissa Barber, Christiana Ruhrberg, Roy O. Weller, Tammaryn Lashley, Jeffrey J. Iliff, Thomas A. Hawkins, Jason Rihel

Acta Neuropathologica

Vasomotor influences on glymphatic-lymphatic coupling and solute trafficking in the central nervous system

James Goodman and Jeffrey Iliff

Journal of Cerebral Blood Flow and Metabolism

CrossTalk Proposal: The glymphatic system supports convective exchange of cerebrospinal fluid and brain interstitial fluid that is mediated by perivascular aquaporin-4

Jeffrey Iliff and Matthew Simon

Journal of Physiology 2019

CrossTalk opposing view: Going against the flow: interstitial solute transport in brain is diffusive and aquaporin‐4 independent (Smith and Verkman)

Rebuttal from Matthew Simon and Jeffrey Iliff

Rebuttal from Alex J. Smith and Alan S. Verkman

Sleep as a Therapeutic Target in the Aging Brain

Thierno Madjou Bah, James Goodman, Jeffrey J. Iliff

Neurotherapeutics 2019

Linking Traumatic Brain Injury, Sleep Disruption and Post-Traumatic Headache: a Potential Role for Glymphatic Pathway Dysfunction

Juan Piantino, Miranda M Lim, Craig D. Newgard, Jeffrey J. Iliff

Current Pain and Headache Reports 2019

In response to “Is solute movement within the extracellular spaces of brain gray matter brought about primarily by diffusion or flow?”

Lori Rey, Jeffrey Iliff, Jeffrey Heys

Fluid and Barriers of the CNS 2019

Pericyte constriction underlies capillary derecruitment during hyperemia in the setting of arterial stenosis

Carmen Methner, Anusha Mishra, Kirsti Golgotiu, Yuandong Li, Wei Wei, N. David Yanez, Berislav Zlokovic, Ruikang K. Wang, Nabil J. Alkayed, Sanjiv Kaul, Jeffrey J. Iliff

American Journal of Physiology: Heart and Circulation Physiology 2019

When the air hits your brain: decreased arterial pulsatility after craniectomy leading to impaired glymphatic flow

Benjamin A. Plog, Nanhong Lou, Clifford A. Pierre, Alex Cove, H. Mark Kenney, Emi Hitomi, Hongyi Kang, Jeffrey J. Iliff, Douglas M. Zeppenfeld, Maiken Nedergaard, G. Edward Vates

Journal of Neurosurgery 2019

Analysis of convective and diffusive transport in the brain interstitium

Lori Ray, Jeffrey Iliff, Jeffrey Heys

Fluid and Barriers of the CNS 2019

Transcriptional network analysis of human astrocytic endfoot genes reveals region-specific associations with dementia status and tau pathology

Matthew J. Simon, Marie X. Wang, Charles F. Murchison, Natalie E. Roese, Erin L. Boespflug, Randall L. Woltjer, Jeffrey J. Iliff

Scientific Reports 2018

Targeted Assessment of Enlargement of the Perivascular Space in Alzheimer’s Disease and Vascular Dementia Subtypes Implicates Astroglial Involvement Specific to Alzheimer’s Disease

Erin L. Boespflug, Matthew Simon, Emmalyn Leonard, Marjorie Grafe, Randall Woltjer, Lisa Silbert, Jeffrey Kaye, Jeffrey Iliff

Journal of Alzheimer’s Disease 2018

Characterization of dural sinus-associated lymphatic vasculature in human Alzheimer’s dementia subjects

James R. Goodman, Zachariah O. Adham, Randall L. Woltjer, Amanda W. Lund. Jeffrey J. Iliff

Brain, Behavior and Immunity 2018

The Emerging Relationship Between Interstitial Fluid–Cerebrospinal Fluid Exchange, Amyloid-β, and Sleep

Erin Boespflug and Jeffrey Iliff

Biological Psychiatry 2018

The effects of noncoding aquaporin-4 single-nucleotide polymorphisms on cognition and functional progression of Alzheimer's disease

Kevin G. Burfeind, Charles F. Murchison, Shawn K. Westaway, Matthew J. Simon, Deniz Erten-Lyons, Jeffrey A. Kaye, Joseph F. Quinn, Jeffrey J. Iliff

Alzheimer's & Dementia: Translational Research & Clinical Interventions 2017

MR Imaging–based Multimodal Autoidentification of Perivascular Spaces (mMAPS): Automated Morphologic Segmentation of Enlarged Perivascular Spaces at Clinical Field Strength

Erin L. Boespflug , Daniel L. Schwartz, David Lahna, Jeffrey Pollock, Jeffrey J. Iliff, Jeffrey A. Kaye, William Rooney, Lisa C. Silbert

Neurology 2018

A transcriptome‐based assessment of the astrocytic dystrophin‐associated complex in the developing human brain

Matthew J. Simon, Charles Murchison, Jeffrey J. Iliff

Journal of Neuroscience Research 2017

Focal Solute Trapping and Global Glymphatic Pathway Impairment in a Murine Model of Multiple Microinfarcts

Minghuan Wang, Fengfei Ding, SaiYue Deng, Xuequn Guo, Wei Wang, Jeffrey J. Iliff and Maiken Nedergaard

Journal of Neuroscience 2017

Association of Perivascular Localization of Aquaporin-4 With Cognition and Alzheimer Disease in Aging Brains

Douglas M. Zeppenfeld, Matthew Simon, J. Douglas Haswell, Daryl D’Abreo, Charles Murchison, Joseph F. Quinn, Marjorie R. Grafe, Randall L. Woltjer, Jeffrey Kaye, Jeffrey J. Iliff

JAMA Neurology 2017

Methamphetamine induces the release of endothelin

Jeong‐Woo Seo, Susan M. Jones, Trisha A. Hostetter, Jeffrey J. Iliff, G. Alexander West

Journal of Neuroscience Research 2016

Regulation of cerebrospinal fluid (CSF) flow in neurodegenerative, neurovascular and neuroinflammatory disease

Matthew J. Simon and Jeffrey J. Iliff

Biochim Biophys Acta 2016

 

OUR RECENT PUBLISHED ABSTRACTS

Glymphatic and meningeal lymphatic function in health and disease.

JJ Iliff. JOURNAL OF NEUROIMMUNE PHARMACOLOGY 14 (2), 337-337.

Decompressive craniectomy impairs glymphatic circulation: syndrome of the trephined

Benjamin A Plog, Nanhong Lou, Clifford Pierre, Alexander Cove, Mark Kenney, Emi Hitomi, Hongyi Kang, Jeffrey Iliff, Douglas Zeppenfeld, Maiken Nedergaard, Edward Vates. JOURNAL OF NEUROSURGERY, 2018.

Identification and Characterization of Human Meningeal Lymphatics

ZO Adham, JR Goodman, R Woltjer, JJ Iliff - Stroke, 2018.

G-protein coupled receptor 39 expression and function in the microcirculation

N Alkayed, Z Cao, C Davis, ZY Qian, F Xie, X Liu, B Li, D Zeppenfeld, M Grafe, J Iliff, X Xiao, A Barnes, S Kaul. JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM (37) 299-300 2017.

Peri-Capillary Pericytes are Associated with Capillary De-Recruitment in the Setting of Non-Critical Stenosis

Carmen Methner, Jeffrey Iliff, Nabil Alkayed, Sanjiv Kaul. The FASEB Journal (31) 831.9-831.9. 2017.

Role of TRP Channels in Mechanical Stimulation Responses of Coronary Pericytes

Eugene Cilento, Zhiping Cao, Jeffrey Iliff, Nabil Alkayed, Sanjiv Kaul. Circulation (134) A19372-A19372 2016.

THE ROLE OF AQUAPORIN-4 (AQP4) SINGLE NUCLEOTIDE POLYMORPHISMS IN COGNITIVE DECLINE

Kevin G Burfeind, Charles F Murchison, Shawn K Westaway, Deniz Erten-Lyons, Jeff A Kaye, Joseph F Quinn, Jeffrey J Iliff. Alzheimer's & Dementia: The Journal of the Alzheimer's Association 12(7) P1036 2016.

PERIVASCULAR AQUAPORIN-4 POLARIZATION IS COMPROMISED IN THE AGING HUMAN BRAIN AND ASSOCIATED WITH AMYLOID BETA PLAQUE DEPOSITION

D Zeppenfeld, J Haswell, M Grafe, R Woltjer, J Iliff. JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM (36) 152 2016.

PERICYTE CONTROL OF THE MICROCIRCULATION IN ISCHEMIC BRAIN

D Zeppenfeld, W Zhu, D Hong, M Grafe, J Iliff, N Alkayed. JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM (36) 549-550 2016.