preprint papers
Aquaporin-4 mislocalization from astrocyte endfeet prolongs survival in a prion-cerebral amyloid angiopathy model
Samantha Flores, Amanda Wilpitz, Daniel Ojeda-Juarez, Jin Wang, Garrett Danque, Paige Sumowski, Gail Funk, Adela Malik, Donald P Pizzo, Emily Richards, Jeffrey J Iliff, Christina J Sigurdson
BioRXiv 2026
Pharmacological enhancement of glymphatic function in humans increases the clearance of Alzheimer’s disease-related proteins
Paul Dagum, Brieann C Satterfield, Laurent Giovangrandi, T Robert Feng, Alejandro Corbellini, Kevin Yarasheski, Brendan P Lucey, Hans Van Dongen, Jeffrey J Iliff, Albert T Cheung
medRxiv 2026
Aquaporin-4 mis-localization slows glymphatic clearance of α-synuclein and promotes α-synuclein pathology and aggregate propagation.
Molly Braun, Matthew J Simon, Jay Jang, Keith Sanderson, Justyna Swierz, Mathew Sevao, Alexandra B Pincus, Allison J Schaser, Jonathan E Elliott, Miranda M Lim, Vivek K Unni, Abigail G Schindler, C Dirk Keene, Caitlin S Latimer, Jeffrey Iliff
bioRxiv 2024.
Glymphatic function restored by α1-noradrenergic antagonism alleviates headache allodynia in mice
Adriana Della Pietra, Adisa Kuburas, Mathew Sevao, Tristen M Castillo, Quinn K Hanigan, Thomas L Duong, Harold C Flinn, Emilie H Partridge, Murray A Raskind, Jeffrey J Iliff, Andrew F Russo
BioRXiv 2026
Sleep Dependent Changes of Lactate Concentration in Human Brain
Selda Yildiz, Miranda M. Lim, Manoj K. Sammi, Katherine Powers, Charles F. Murchison, Jeffrey J. Iliff, William D. Rooney
bioRxiv 2021
Published Papers
Obstructive Sleep Apnea, Positive Airway Pressure, and Implications of Early Treatment in Parkinson Disease
Lee E Neilson, Isabella Montaño, Jasmine L May, Savanah Sicard, Yeilim Cho, Jeffrey J Iliff, Jonathan E Elliott, Miranda M Lim, Gregory D Scott
JAMA Neurology 2026
Antiseizure medication effects on sleep architecture in epilepsy: Glymphatic insights and implications for cognitive decline
Justyna Swierz, Michael Doherty, Sung Ji, Jeffrey Iliff, Yeilim Cho
Epilepsy Research 2026
Dynamic MRI of Fluid and Solute Transportation across the Arachnoid Barrier in the Human Meninges
Yinghao Li, Yuanqi Sun, Adrian Paez, Gaoqiang Xu, Jay J Pillai, Jeffrey J Iliff, Sandeep K Ganji, Linda Knutsson, Peter CM Van Zijl, David O Kamson, Peter A Calabresi, Jun Hua
Radiology 2026
Alterations in CSF amyloid-β and tau biomarkers in former college and professional American football players: Findings from the DIAGNOSE CTE Research Project
Deidre Jansson, Jane Shofer, Elizabeth Colasurdo, Abigail Schindler, Ge Li, Charles H Adler, Laura Balcer, Charles Bernick, Daniel Daneshvar, Douglas Katz, Michael McClean, Jesse Mez, Joseph Palmisano, Nicholas Ashton, Kaj Blennow, Henrik Zetterberg, Yorghos Tripodis, Michael L Alosco, Jeffrey L Cummings, Eric M Reiman, Martha Shenton, Robert A Stern, Jeffrey Iliff, Elaine R Peskind, DIAGNOSE CTE Research Project
Journal of Neurotrauma 2026
Diurnal choroid plexus function in mice depends on sex, age, and amyloid-β status
Deidre Jansson, Ryan O’Boyle, Taylor J Pedersen, Elizabeth Gino, Mathew Sevao, Ron Vered, Katherine L Suchland, Blake Zhou, Ryann Fame, Samantha A Keil, Molly Braun, Jeffrey Iliff
Communications Biology 2026
The effects of elevated CO2 on brain and ocular signal intensity with intravenous contrast MRI
Rachael D Seidler, Sutton B Richmond, Swati Rane Levendovzsky, Mehmet Albayram, Jeffrey J Iliff, Dawn Kernagis, Isabella Abad, Jens T Rosenberg
Journal of Neurophysiology 2026
The glymphatic system clears amyloid beta and tau from brain to plasma in humans
Paul Dagum, Donald L Elbert, Laurent Giovangrandi, Tarandeep Singh, Venky V Venkatesh, Alejandro Corbellini, Robert M Kaplan, Swati Rane Levendovszky, Elizabeth Ludington, Kevin Yarasheski, Jeffrey Lowenkron, Carla VandeWeerd, Miranda M Lim, Jeffrey J Iliff
Nature Communications 2025
Resolving the mysteries of brain clearance and immune surveillance
Jonathan Kipnis, Helene Benveniste, Anne Eichmann, Jean-Leon Thomas, Daniel S Reich, Laura D Lewis, Li-Huei Tsai, Antoine Drieu, Erik NTP Bakker, Douglas H Kelley, Iben Lundgaard, Humberto Mestre, Benedikt Zott, Per Kristian Eide, Matthias JP van Osch, Susanne J van Veluw, Jeffrey Iliff, Andrew C Yang, Laura Santambrogio, Sandro Da Mesquita, Richard Daneman, Justin Rustenhoven, Steven A Goldman, Maiken Nedergaard
Neuron 2025
Biological Sex and Body Mass Index Influence the Longitudinal Evolution of Adolescent and Young Adult Magnetic Resonance Imaging-Visible Perivascular Spaces
Erin A Yamamoto, Seiji Koike, Caitlyn Wong, Laura E Dennis, Madison N Luther, Avery Scatena, Seva Khambadkone, Jeffrey J Iliff, Miranda M Lim, Swati R Levendovszky, Jonathan E Elliott, Giuseppe Barisano, Eva M Müller-Oehring, Angelica M Morales, Fiona C Baker, Bonnie J Nagel, Juan Piantino
Pediatric Neurology 2025
Glymphatic dysfunction in Alzheimer’s disease: A critical appraisal
Samantha A Keil, Deidre Jansson, Molly Braun, Jeffrey J Iliff
Science 2025
A wireless device for continuous measurement of brain parenchymal resistance tracks glymphatic function in humans
Paul Dagum, Laurent Giovangrandi, Swati Rane Levendovszky, Jake J Winebaum, Tarandeep Singh, Yeilim Cho, Robert M Kaplan, Michael S Jaffee, Miranda M Lim, Carla Vandeweerd, Jeffrey J Iliff
Nature Biomedical Engineering 2025
The role of transient receptor potential melastatin channels in compressive force‐induced contraction of primary cardiac pericytes
Carmen Methner, Eugene Cilento, Zhiping Cao, Jeffrey Iliff, Anusha Mishra, Sanjiv Kaul
Physiological Reports 2025
Catecholamine Dysregulation in Former American Football Players: Findings From the DIAGNOSE CTE Research Project
Suzan van Amerongen, Elaine R Peskind, Yorghos Tripodis, Charles H Adler, Laura J Balcer, Charles Bernick, Michael L Alosco, Douglas Katz, Sarah J Banks, William B Barr, Robert C Cantu, David W Dodick, Yonas E Geda, Jesse Mez, Jennifer V Wethe, Jason L Weller, Daniel H Daneshvar, Joseph Palmisano, Tess Fagle, Minna Holleck, Bailey Kossow, Surya Pulukuri, Fatima Tuz-Zahra, Elizabeth Colasurdo, Carl Sikkema, Jeffrey Iliff, Ge Li, Martha E Shenton, Eric M Reiman, Jeffrey L Cummings, Robert A Stern, DIAGNOSE CTE Research Project
Neurology 2025
Focused Ultrasound Enhances Glymphatic Transport Robustly Across Anesthesia Levels
Haijun Xiao, Abhijith Sreejith, Iylan Howson, Alexander Aviles Cruz, Taylor Key, Jeffrey J Iliff, Muna Aryal
Ultrasound in Medicine & Biology 2025
Glymphatic influx and clearance are perturbed in Huntington’s disease
Hongshuai Liu, Lin Chen, Chuangchuang Zhang, Chang Liu, Yuguo Li, Liam Cheng, Yuxiao Ouyang, Catherine Rutledge, John Anderson, Zhiliang Wei, Ziqin Zhang, Hanzhang Lu, Peter CM Van Zijl, Jeffrey J Iliff, Jiadi Xu, Wenzhen Duan
JCI insight 2024.
Repetitive head impacts and perivascular space volume in former american football players
Leonard B Jung, Tim LT Wiegand, Fatima Tuz-Zahra, Yorghos Tripodis, Jeffrey J Iliff, Juan Piantino, Hector Arciniega, Cara L Kim, Lara Pankatz, Sylvain Bouix, Alexander P Lin, Michael L Alosco, Daniel H Daneshvar, Jesse Mez, Farshid Sepehrband, Yogesh Rathi, Ofer Pasternak, Michael J Coleman, Charles H Adler, Charles Bernick, Laura Balcer, Jeffrey L Cummings, Eric M Reiman, Robert A Stern, Martha E Shenton, Inga K Koerte, Yi Su, Kewei Chen, Hillary Protas, Conni Boker, Rhoda Au, Robert C Cantu, Lindsay Farrer, Robert Helm, Neil Kowall, Gustavo Mercier, James Otis, Jason Weller, Irene Simkin, Alondra Andino, Shannon Conneely, Courtney Diamond, Tessa Fagle, Olivia Haller, Tennyson Hung, Nicole Gullotti, Megan Mariani, Brian Mayville, Kathleen McLaughlin, Mary Nanna, Taylor Platt, Sury Pulukuri, Fiona Rica, Madison Sestak, Michael McClean, Douglas Annis, Christine Chaisson, Dianne B Dixon, Carolyn Finney, Kerrin Gallagher, Kaitlin Hartlage, Jun Lu, Brett Martin, Emmanuel Ojo, Joseph N Palmisano, Brittany Pine, Janani Ramachandran, Jennifer Fitzsimmons, Elena M Bonke, Katherine Breedlove, Eduardo Coello, Hujiun Liao, Elizabeth Rizzoni, Vivian Schultz, Annelise Silva, Brynn Vessey, Sarah Banks, Jason Miller, Aaron Ritter, Raelynn de la Cruz, Jan Durant, Moragn Golceker, Nicolette Harmon, Kaeson Kaylegian, Rachelle Long, Christin Nance, Priscilla Sandoval, Robert W Turner, Kenneth L Marek, Andrew Serrano, David W Dodick, Yonas Geda, Jennifer V Wethe, Bryce Falk, Amy Duffy, Marci Howard, Michelle Montague, Thomas Osgood, Debra Babcock, William Barr, Judith Goldberg, Thomas Wisniewski, Ivian Kirov, Yvonne Lui, Charles Marmar, Lisene Hasanaj, Liliana Serrano, Alhassan Al-Kharafi, Allan George, Sammie Martin, Edward Riley, William Runge, Elaine R Peskind, Elizabeth Colasurdo, Daniel S Marcus, Jenny Gurney, Keith A Johnson, Richard Greenwald
JAMA Network Open 2024.
Macroscopic changes in aquaporin-4 underlie blast traumatic brain injury-related impairment in glymphatic function
Molly Braun, Mathew Sevao, Samantha A Keil, Elizabeth Gino, Marie X Wang, Janet Lee, Mariya A Haveliwala, Emily Klein, Sanjana Agarwal, Taylor Pedersen, C Harker Rhodes, Deidre Jansson, David Cook, Elaine Peskind, Daniel P Perl, Juan Piantino, Abigail G Schindler, Jeffrey J Iliff
Brain 2024
Preliminary investigations into human neurofluid transport using multiple novel non-contrast MRI methods
Swati Rane Levendovszky, Jacqueline Flores, Elaine Peskind, Lena Vaclavu, Matthias van Osch, Jeffrey Iliff
Journal of Cerebral Blood Flow and Metabolism 2024
Is CAA a perivascular brain clearance disease? A discussion of the evidence to date and outlook for future studies
Susanne J. van Veluw, Helene Benveniste, Erik N. T. P. Bakker, Roxana O. Carare ,Steven M. Greenberg ,Jeffrey J. Iliff, Sylvie Lorthois, William E. Van Nostrand, Gabor C. Petzold, Andy Y. Shih, Matthias J. P. van Osch
Cellular and Molecular Life Sciences 2024
Emerging Insights into the Interstitial Distribution of Neuraxial Therapeutics via the Cerebrospinal Fluid Compartment
Deidre J Jansson, Jeffrey J Iliff
Neuraxial Therapeutics: A Comprehensive Guide 2024
Perivascular space burden and cerebrospinal fluid biomarkers in US Veterans with blast-related mild traumatic brain injury
Erin A Yamamoto, Seiji Koike, Madison Luther, Laura Dennis, Miranda M Lim, Murray Raskind, Kathleen Pagulayan, Jeffrey Iliff, Elaine Peskind, Juan A Piantino
Journal of Neurotrauma 2024
Inflammatory biomarkers for neurobehavioral dysregulation in former American football players: findings from the DIAGNOSE CTE Research Project
Suzan van Amerongen, Surya V Pulukuri, Fatima Tuz-Zahra, Yorghos Tripodis, Jonathan D Cherry, Charles Bernick, Yonas E Geda, Jennifer V Wethe, Douglas I Katz, Michael L Alosco, Charles H Adler, Laura J Balcer, Nicholas J Ashton, Kaj Blennow, Henrik Zetterberg, Daniel H Daneshvar, Elizabeth A Colasurdo, Jeffrey J Iliff, Gail Li, Elaine R Peskind, Martha E Shenton, Eric M Reiman, Jeffrey L Cummings, Robert A Stern
Journal of Neuroinflammation 2024
Glymphatic and lymphatic communication with systemic responses during physiological and pathological conditions in the central nervous system.
Ester Licastro, Giuseppe Pignataro, Jeffrey J Iliff, Yanxiao Xiang, Eng H Lo, Kazuhide Hayakawa, Elga Esposito
Communications Biology 2024
Dynamic changes in perivascular space morphology predict signs of spaceflight-associated neuro-ocular syndrome in bed rest.
Sutton B Richmond, Rachael D Seidler, Jeffrey J Iliff, Daniel L Schwartz, Madison Luther, Lisa C Silbert, Scott J Wood, Jacob J Bloomberg, Edwin Mulder, Jessica K Lee, Alberto De Luca, Juan Piantino
Microgravity 2024
CSF β-amyloid and tau biomarker changes in Veterans with mild traumatic brain injury.
Ge Li, Jeffrey Iliff, Jane Shofer, Cynthia L Mayer, James Meabon, David Cook, Kathleen F Pagulayan, Murray A Raskind, Henrik Zetterberg, Kaj Blennow, Elaine R Peskind
Neurology 2024
Longitudinal Sleep Patterns and Cognitive Impairment in Older Adults
Samantha A Keil, Abigail Schindler, Marie X Wang, Juan Piantino, Lisa C Silbert, Jonathan E Elliott, Madeleine Werhane, Ronald Thomas, Sherry Willis, Miranda Lim, Jeffrey Iliff
JAMA Network Open 2023
Neuronal Ndst1 depletion accelerates prion protein clearance and slows neurodegeneration in prion infection
Aguilar-Calvo P , Malik A , Sandoval DR , Barback C , Orrù CD , Standke HG , Thomas O , Dwyer CA , Pizzo DP , Bapat J , Soldau K , Ogawa R , Riley MB , Nilsson KPR , Kraus A , Caughey B , Iliff JJ , Vera D , Esko JD , Sigurdson CJ
PLOS Pathology 2023
A case of prazosin in treatment of rapid eye movement sleep behavior disorder
Yeilim Cho, Jeffrey Iliff, Miranda Lim, Murray Raskind, Elaine Peskind
Journal of Clinical Sleep Medicine 2023
Emerging Perspectives on MRI Application in Multiple Sclerosis: Moving from Pathophysiology to Clinical Practice
Maria Assunta Rocca, Monica Margoni, Marco Battaglini, Arman Eshaghi, Jeffrey Iliff, Elisabetta Pagani, Paolo Preziosa, Loredana Storelli, Toshiaki Taoka, Paola Valsasina, Massimo Filippi
Radiology 2023
The effect of aquaporin-4 mis-localization on Aβ deposition in mice
Taylor J Pedersen, Samantha A Keil, Warren Han, Marie X Wang, Jeffrey J Iliff
Neurobiology of Disease 2023
Quantification approaches for magnetic resonance imaging following intravenous gadolinium injection: A window into brain‐wide glymphatic function
Sutton B Richmond, Swati Rane, Moriah R Hanson, Mehmet Albayram, Jeffrey J Iliff, Dawn Kernagis, Jens T Rosenberg, Rachael D Seidler
European Journal of Neuroscience 2023
Reader Response: Association of Sleep, Neuropsychological Performance, and Gray Matter Volume With Glymphatic Function in Community-Dwelling Older Adults
Juan A Piantino, Jeffrey J Iliff, Miranda M Lim, Swati Rane Levendovszky
Neurology 2023
Mapping the lymphatic system across body scales and expertise domains: A report from the 2021 National Heart, Lung, and Blood Institute workshop at the Boston Lymphatic Symposium
Dhruv Singhal, Katy Börner, Elliot L Chaikof, Michael Detmar, Maija Hollmén, Jeffrey J Iliff, Maxim Itkin, Taija Makinen, Guillermo Oliver, Timothy P Padera, Ellen M Quardokus, Andrea J Radtke, Hiroo Suami, Griffin M Weber, Ilsa I Rovira, Selen C Muratoglu, Zorina S Galis
Frontiers in Physiology 2023
Locoregional CAR T cells for children with CNS tumors: clinical procedure and catheter safety
Nicholas A Vitanza, Rebecca Ronsley, Michelle Choe, Casey Henson, Mandy Breedt, Adriel Barrios-Anderson, Amy Wein, Christopher Brown, Adam Beebe, Ada Kong, Danielle Kirkey, Brittany M Lee, Sarah ES Leary, Erin E Crotty, Corrine Hoeppner, Susan Holtzclaw, Ashley L Wilson, Joshua A Gustafson, Jessica B Foster, Jeffrey J Iliff, Hannah E Goldstein, Samuel R Browd, Amy Lee, Jeffrey G Ojemann, Navin Pinto, Juliane Gust, Rebecca A Gardner, Michael C Jensen, Jason S Hauptman, Julie R Park
Neoplasia 2023
The glymphatic system: Current understanding and modeling
Bohr T, Hjorth PG, Holst SC, Hrabětová S, Kiviniemi V, Lilius T, Lundgaard I, Mardal KA, Martens EA, Mori Y, Nägerl UV, Nicholson C, Tannenbaum A, Thomas JH, Tithof J, Benveniste H, Iliff JJ, Kelley DH, Nedergaard M.
iScience 2022
Dynamic infrared imaging of cerebrospinal fluid tracer influx into the brain
Samantha A. Keil, Molly Braun, Ryan O'Boyle, Mathew Sevao, Taylor Pedersen, Sanjana Agarwal, Deidre Jansson, Jeffrey J. Illiff
Neurophotonics 2022
Loss of perivascular aquaporin-4 localization impairs glymphatic exchange and promotes amyloid beta plaque formation in mice
Matthew Simon, Marie Xun Wang, Ozama Ismail, Molly Braun, Abigail G. Schindler, Jesica Reemmer, Zhongya Wang, Mariya A. Haveliwala, Ryan P. O’Boyle, Warren Y. Han, Natalie Roese, Marjorie Grafe, Randall Woltjer, Detlev Boison, Jeffrey J. Iliff
Alzheimer’s Research & Therapy 2022
Longitudinal MRI-visible perivascular space (PVS) changes with long-duration spaceflight
Kathleen E. Hupfeld, Sutton B. Richmond, Heather R. McGregor, Daniel L. Schwartz, Madison Luther, Nichole E. Beltran, Igor S. Kofman, Yiri E. De Dios, Roy F. Riascos, Scott J. Wood, Jacob J. Bloomberg, Ajitkumar P. Mulavara, Lisa Silbert, Jeffrey J. Iliff, Rachael D. Seidler, Juan Piantino
Scientific Reports 2022
Markers of cerebrovascular injury, inflammation, and plasma lipids are associated with Alzheimer’s disease cerebrospinal fluid biomarkers in cognitively normal persons
Deidre Jansson, Marie Wang, Ronald Thomas, Michelle Erickson, Elaine Peskind, Ge Li, Jeffrey Iliff
Journal of Alzheimer’s Disease 2022
Impaired glymphatic function and pulsation alterations in a mouse model of vascular cognitive impairment
Mosi Li, Akihiro Kitamura, Joshua Beverley, Juraj Koudelka, Jessica Duncombe, Ross Lennen, Maurits Jansen, Ian Marshall, Bettina Platt, Ulrich K. Wiegand, Roxana O. Carare, Rajesh N. Kalaria, Jeffrey Iliff, Karen Horsburgh
Frontiers in Aging Neuroscience 2022
Quantitative analysis of macroscopic solute transport in the murine brain
Lori A Ray, Martin Pike, Mathew Simon, Jeffrey J Iliff, Jeffrey J Heys
Fluid and Barriers of the CNS 2021
Emerging roles for dynamic aquaporin-4 subcellular relocalization in CNS water homeostasis
Mootaz Salman, Philip Kitchen, Andrea Halsey, Marie Wang, Susanna Tornroth-Horsefield, Alex Conner, Jerome Badaut, Jeffrey Iliff, Roslyn Bill
Brain 2021
Aquaporin-4 and glymphatic flow have central roles in brain fluid homeostasis.
Mootaz Salman, Philip Kitchen, Jeffrey Iliff, Roslyn Bill
Nature Reviews Neuroscience 2021
Role of endothelium-pericyte signaling in capillary blood flow response to neuronal activity.
Wenri Zhang, Catherine Davis, Douglas Zeppenfeld, Kirsti Golgotiu, Marie Wang, Mariya Haveliwala, Daniel Hong, Yuandong Li, Ruikang Wang, Jeffrey Iliff, Nabil Alkayed.
Journal of Cerebral Blood Flow and Metabolism 2021
Link between mild traumatic brain injury, poor sleep, and MRI-visible perivascular spaces in Veterans.
Juan Piantino, Daniel Schwartz, Madison Luther, Craig Newgard, Lisa Silbert, Murray Raskind, Kathleen Pagulayan, Natalia Kleinhans, Jeffrey Iliff, Elaine Peskind.
Journal of Neurotrauma 2021
Varying perivascular astroglial endfoot dimensions along the vascular tree maintain perivascular-interstitial flux through the cortical mantle.
Marie Xun Wang, Lori Rey, Kenji F. Tanaka, Jeffrey J. Iliff, Jeffrey Heys
Glia 2021
Transcriptional signatures in histologic structures within glioblastoma tumors may predict personalized drug sensitivity and survival
Cymon N Kersch, Cheryl J Claunch, Prakash Ambady, Elmar Bucher, Daniel L Schwartz, Ramon F Barajas Jr, Jeffrey J Iliff, Tyler Risom, Laura Heiser, Leslie L Muldoon, James E Korkola, Joe W Gray, Edward A Neuwelt
Neuro-Oncology Advances 2020
The impact of neurovascular, blood-brain barrier, and glymphatic dysfunction in neurodegenerative and metabolic diseases
Molly Braun and Jeffrey J. Iliff
International Review of Neurobiology 2020
Structural and functional conservation of non-lumenized lymphatic endothelial cells in the mammalian leptomeninges
Shannon Shibata-Germanos, James R. Goodman, Alan Grieg, Chintan A. Trivedi, Bridget C. Benson, Sandrine C. Foti, Ana Faro, Raphael F. P. Castellan, Rosa Maria Correra, Melissa Barber, Christiana Ruhrberg, Roy O. Weller, Tammaryn Lashley, Jeffrey J. Iliff, Thomas A. Hawkins, Jason Rihel
Acta Neuropathologica 2020
Vasomotor influences on glymphatic-lymphatic coupling and solute trafficking in the central nervous system
James Goodman and Jeffrey Iliff
Journal of Cerebral Blood Flow and Metabolism 2020
CrossTalk Proposal: The glymphatic system supports convective exchange of cerebrospinal fluid and brain interstitial fluid that is mediated by perivascular aquaporin-4
Jeffrey Iliff and Matthew Simon
Journal of Physiology 2019
Sleep as a Therapeutic Target in the Aging Brain
Thierno Madjou Bah, James Goodman, Jeffrey J. Iliff
Neurotherapeutics 2019
Linking Traumatic Brain Injury, Sleep Disruption and Post-Traumatic Headache: a Potential Role for Glymphatic Pathway Dysfunction
Juan Piantino, Miranda M Lim, Craig D. Newgard, Jeffrey J. Iliff
Current Pain and Headache Reports 2019
In response to “Is solute movement within the extracellular spaces of brain gray matter brought about primarily by diffusion or flow?”
Lori Rey, Jeffrey Iliff, Jeffrey Heys
Fluid and Barriers of the CNS 2019
Pericyte constriction underlies capillary derecruitment during hyperemia in the setting of arterial stenosis
Carmen Methner, Anusha Mishra, Kirsti Golgotiu, Yuandong Li, Wei Wei, N. David Yanez, Berislav Zlokovic, Ruikang K. Wang, Nabil J. Alkayed, Sanjiv Kaul, Jeffrey J. Iliff
American Journal of Physiology: Heart and Circulation Physiology 2019
When the air hits your brain: decreased arterial pulsatility after craniectomy leading to impaired glymphatic flow
Benjamin A. Plog, Nanhong Lou, Clifford A. Pierre, Alex Cove, H. Mark Kenney, Emi Hitomi, Hongyi Kang, Jeffrey J. Iliff, Douglas M. Zeppenfeld, Maiken Nedergaard, G. Edward Vates
Journal of Neurosurgery 2019
Analysis of convective and diffusive transport in the brain interstitium
Lori Ray, Jeffrey Iliff, Jeffrey Heys
Fluid and Barriers of the CNS 2019
Aquaporin-4-dependent glymphatic solute transport in the rodent brain
Humberto Mestre, Lauren M Hablitz, Anna LR Xavier, Weixi Feng, Wenyan Zou, Tinglin Pu, Hiromu Monai, Giridhar Murlidharan, Ruth M Castellanos Rivera, Matthew J Simon, Martin M Pike, Virginia Plá, Ting Du, Benjamin T Kress, Xiaowen Wang, Benjamin A Plog, Alexander S Thrane, Iben Lundgaard, Yoichiro Abe, Masato Yasui, John H Thomas, Ming Xiao , Hajime Hirase , Aravind Asokan , Jeffrey J Iliff , Maiken Nedergaard
eLife 2018
Transcriptional network analysis of human astrocytic endfoot genes reveals region-specific associations with dementia status and tau pathology
Matthew J. Simon, Marie X. Wang, Charles F. Murchison, Natalie E. Roese, Erin L. Boespflug, Randall L. Woltjer, Jeffrey J. Iliff
Scientific Reports 2018
Targeted Assessment of Enlargement of the Perivascular Space in Alzheimer’s Disease and Vascular Dementia Subtypes Implicates Astroglial Involvement Specific to Alzheimer’s Disease
Erin L. Boespflug, Matthew Simon, Emmalyn Leonard, Marjorie Grafe, Randall Woltjer, Lisa Silbert, Jeffrey Kaye, Jeffrey Iliff
Journal of Alzheimer’s Disease 2018
Characterization of dural sinus-associated lymphatic vasculature in human Alzheimer’s dementia subjects
James R. Goodman, Zachariah O. Adham, Randall L. Woltjer, Amanda W. Lund. Jeffrey J. Iliff
Brain, Behavior and Immunity 2018
The Emerging Relationship Between Interstitial Fluid–Cerebrospinal Fluid Exchange, Amyloid-β, and Sleep
Erin Boespflug and Jeffrey Iliff
Biological Psychiatry 2018
The effects of noncoding aquaporin-4 single-nucleotide polymorphisms on cognition and functional progression of Alzheimer's disease
Kevin G. Burfeind, Charles F. Murchison, Shawn K. Westaway, Matthew J. Simon, Deniz Erten-Lyons, Jeffrey A. Kaye, Joseph F. Quinn, Jeffrey J. Iliff
Alzheimer's & Dementia: Translational Research & Clinical Interventions 2017
Neurovascular Unit: Basic and Clinical Imaging with Emphasis on Advantages of Ferumoxytol
Neurosurgery 2018
MR Imaging–based Multimodal Autoidentification of Perivascular Spaces (mMAPS): Automated Morphologic Segmentation of Enlarged Perivascular Spaces at Clinical Field Strength
Erin L. Boespflug , Daniel L. Schwartz, David Lahna, Jeffrey Pollock, Jeffrey J. Iliff, Jeffrey A. Kaye, William Rooney, Lisa C. Silbert
Neurology 2018
A transcriptome‐based assessment of the astrocytic dystrophin‐associated complex in the developing human brain
Matthew J. Simon, Charles Murchison, Jeffrey J. Iliff
Journal of Neuroscience Research 2017
Focal Solute Trapping and Global Glymphatic Pathway Impairment in a Murine Model of Multiple Microinfarcts
Minghuan Wang, Fengfei Ding, SaiYue Deng, Xuequn Guo, Wei Wang, Jeffrey J. Iliff and Maiken Nedergaard
Journal of Neuroscience 2017
Association of Perivascular Localization of Aquaporin-4 With Cognition and Alzheimer Disease in Aging Brains
Douglas M. Zeppenfeld, Matthew Simon, J. Douglas Haswell, Daryl D’Abreo, Charles Murchison, Joseph F. Quinn, Marjorie R. Grafe, Randall L. Woltjer, Jeffrey Kaye, Jeffrey J. Iliff
JAMA Neurology 2017
Methamphetamine induces the release of endothelin
Jeong‐Woo Seo, Susan M. Jones, Trisha A. Hostetter, Jeffrey J. Iliff, G. Alexander West
Journal of Neuroscience Research 2016
Regulation of cerebrospinal fluid (CSF) flow in neurodegenerative, neurovascular and neuroinflammatory disease
Matthew J. Simon and Jeffrey J. Iliff
Biochim Biophys Acta 2016