The mission of the Iliff Lab is to better understand the cellular and molecular processes underlying traumatic brain injury (TBI) and neurodegenerative diseases, such as Alzheimer’s and Parkinson’s disease. Through a greater understanding of how these conditions appear ‘in the wild’ in the human brain, and their underlying mechanisms defined in animal models, our goal is to fundamentally change the way that these conditions are understood and treated in the next 15 years.
To accomplish these goals, we focus on four key resources:
Appropriate use of advanced cellular and imaging approaches
Strategic collaborative relationships
Sustainable, diversified funding
The failure of translational neuroscience in the TBI, stroke and neurodegenerative fields to develop clinically-effective treatments for these conditions suggests that many of the things that our research fields ‘know’ may not be true in fact. We believe that rigorous characterization, with careful attention paid to spatial and anatomical relationships, reproducibility, and with a humble and self-critical approach to our own work, will provide a path to discovery that will impact the treatment of human disease.